CISTATINA C PDF

The journal, published since , is the official publication of the Spanish Society of Cardiology and founder of the REC Publications journal family. Articles are published in both English an Spanish in its electronic edition. The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two receding years. CiteScore measures average citations received per document published. Read more.

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Purpose: Cystatin C has a higher correlation with glomerular filtration rate and a more significant clinical prognosis than creatinine. We sought to determine whether it is a marker of renal function different from creatinine cystatin C potentially superior to creatinine , in patients with systemic lupus erythematosus.

Material and methods: 37 patients with systemic lupus erythematosus were evaluated. Serum cystatin C was determined by nephelometry and creatinine by modified Jaffe method. We analyzed the influence of clinical and laboratory factors in cystatin C variation, using multivariate linear regression. Discussion: Several reports showed cystatin C as a better marker to define chronic kidney disease, allowing more accurate classification and risk stratification, compared with creatinine.

In this study, Cystatin C revealed as a promisor marker of renal function in patient with lupus, mainly in patients with lower glomerular filtration rates. The correlation between age and cystatin C seems to be a confounding factor, as glomerular filtration rate physiologically declines with ageing. Conclusion: Cystatin C was potentially superior to creatinine and in this study and cystatin C seems to detect changes in glomerular filtration rate earlier than creatinine and may be a better screening method for chronic kidney disease in systemic lupus erythematosus.

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Full-text links Cite Favorites. Abstract in English , Portuguese. Similar articles Serum cystatin C is associated with kidney function but not with cardiovascular risk factors or subclinical atherosclerosis in patients with Systemic Lupus Erythematosus.

Garcia-Garcia P, et al. Clin Rheumatol. Epub Sep PMID: Serum cystatin C is independently associated with renal impairment and high sensitivity C-reactive protein in systemic lupus erythematosus. Chew C, et al. Clin Exp Rheumatol. Epub Dec Comparison of cystatin C- and creatinine-based estimation of glomerular filtration rate according to glycaemic status in Type 2 diabetes. Oh SJ, et al. Diabet Med. Glomerular filtration rate estimation: performance of serum cystatin C-based prediction equations.

Weinert LS, et al. Clin Chem Lab Med. Epub Jul PMID: Review. Cystatin C as a biomarker for estimating glomerular filtration rate. Ferguson TW, et al. Curr Opin Nephrol Hypertens. Show more similar articles See all similar articles. Publication types Observational Study Actions. MeSH terms Adult Actions. Aged Actions. Aged, 80 and over Actions. Cross-Sectional Studies Actions. Female Actions. Glomerular Filtration Rate Actions. Humans Actions.

Male Actions. Middle Aged Actions. Prospective Studies Actions. Young Adult Actions. Substances Biomarkers Actions. Cystatin C Actions.

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Cystatin C: A Promising Marker of Renal Function in Patients With Systemic Lupus Erythematosus?

Purpose: Cystatin C has a higher correlation with glomerular filtration rate and a more significant clinical prognosis than creatinine. We sought to determine whether it is a marker of renal function different from creatinine cystatin C potentially superior to creatinine , in patients with systemic lupus erythematosus. Material and methods: 37 patients with systemic lupus erythematosus were evaluated. Serum cystatin C was determined by nephelometry and creatinine by modified Jaffe method. We analyzed the influence of clinical and laboratory factors in cystatin C variation, using multivariate linear regression. Discussion: Several reports showed cystatin C as a better marker to define chronic kidney disease, allowing more accurate classification and risk stratification, compared with creatinine. In this study, Cystatin C revealed as a promisor marker of renal function in patient with lupus, mainly in patients with lower glomerular filtration rates.

INTERPRETACION DE HISTOGRAMAS EN HEMATOLOGIA PDF

Serum cystatin C: a practical alternative for renal function evaluation? Vantagens e desvantagens desse marcador foram aqui discutidas. Despite incontestable advances in medicine, it is still difficult to define precisely this test in clinical practice. Early markers of renal lesion are important, because glomerular filtration rate usually decreases before the first chronic renal failure symptoms or signs appear. Cystatin C has been pointed as an alternative, but it was not tested in many diseases. Advantages and disadvantages of this marker are discussed. Although serum cystatin C determination is increasingly being used in clinical practice worldwide, its limitations as well as the conditions its use is in fact indicated are not adequately established; on the other hand serum creatinine and creatinine clearance is an easily available and low cost laboratory marker with well-known limitations that can be used routinely in the assessment of renal function.

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