FOSFATIDILINOSITOL FUNCION PDF

Eyster KM. The membrane and lipids as integral participants in signal transduction: lipid signal transduction for the non-lipid biochemist. Adv Physiol Educ ; Activation of phospholipase C beta 2 by the alpha and beta gamma subunits of trimeric GTP-binding protein. Caulfield MP.

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Eyster KM. The membrane and lipids as integral participants in signal transduction: lipid signal transduction for the non-lipid biochemist. Adv Physiol Educ ; Activation of phospholipase C beta 2 by the alpha and beta gamma subunits of trimeric GTP-binding protein.

Caulfield MP. Muscarinic receptors-characterization, coupling and function. Pharmacol Ther ; McLaughlin S, Murray D. Plasma membrane phosphoinositide organization by protein electrostatics. Nature ; PTEN and myotubularin phosphatases: from 3-phosphoinositide dephosphorylation to disease. Trends Cell Biol ; Huang CL.

Complex roles of PIP2 in the regulation of ion channels and transporters. Am J Physiol Renal Physiol ; Suh BC, Hille B. Regulation of ion channels by phosphatidylinositol 4,5-bisphosphate. Curr Opin Neurobiol ; Annu Rev Biophys ; Hilgemann DW, Ball R. Science ; Functional coupling of Kir6. J Gen Physiol ; Membrane phospholipid control of nucleotide sensitivity of KATP channels.

Regulation of M Kv7. J Physiol ; Recovery from muscarinic modulation of M current channels requires phosphatidylinositol 4,5- bisphosphate synthesis. Neuron ; Relationship between membrane phosphatidylinositol-4,5-bisphosphate and receptor-mediated inhibition of native neuronal M channels. J Neurosci ; Cholinergic suppression of KCNQ channel currents enhances excitability of striatal medium spiny neurons. Direct activation of inward rectifier potassium channels by PIP2 and its stabilization by Gbetagamma.

D1 and D2 dopamine receptor modulation of striatal glutamatergic signaling in striatal medium spiny neurons. Trends Neurosci ; Cholinergic modulation of Kir2 channels selectively elevates dendritic excitability in striatopallidal neurons.

Nat Neurosci ; M1 muscarinic receptor modulation of Kir2 channels enhances temporal summation of excitatory synaptic potentials in prefrontal cortex pyramidal neurons. J Neurophysiol ; Direct regulation of BK channels by phosphatidylinositol 4,5-biphosphate as a novel signaling pathway. Presynaptic signaling by heterotrimeric G-proteins. Handb Exp Pharmacol ; Dual regulation of voltage gated calcium channels by PtdIns 4,5 P2.

Neuroscience ; Calcium channel regulation and presynaptic plasticity. Cholinergic control of firing pattern and neurotransmission in rat neostriatal projection neurons: role of CaV2. Circ Res ; Physiologic regulation of the epithelial sodium channel by phosphatidylinositides. Curr Opin Nephrol Hypertens ; Mol Neurobiol ; Bradykinin and nerve growth factor release the capsaicin receptor from PtdIns 4,5 P2-mediated inhibition.

Prescott ED, Julios D. A modular PIP2 binding site as a determinant of capsaicin receptor sensitivity. Functional recovery from desensitization of vanilloid receptor TRPV1 requires resynthesis of phosphatidylinositol 4,5-bisphosphate. Yao J, Qin F. Interaction with phosphoinositides confers adaptation onto the TRPV1 pain receptor. PLoS Biol ; 7:e Liu B, Qin F. Functional of cold- and menthol-sensitive TRPM8 ion channels by phosphatidylinositol 4,5- bisphosphate.

DESPIERTATE SALTERIO Y ARPA PDF

Glicosilfosfatidilinositol

De esta transferencia se forma GlcNAc-P. Una vez llega a la membrana, se une a esta quedando el GPI en la cara extracelular. Un ejemplo de control primario se encuentra en las diferencias en las cadenas laterales de glicanos en las GPI en la enzima membrana dipeptidasa entre humanos y bovinos. Y un ejemplo de control secundario es la diferencia entre las cadenas laterales de glicano de VSG V ariant S urface G licoprotein cuando algunas de estas enzimas con diferentes secuencias carboxi-terminales se expresan en el mismo trypanosoma. El GPI no es de gran importancia en la primera, pero en su segunda forma hace uso de receptores de transferrina que se encuentran anclados a GPI.

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