AR 746-2 PDF

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Remacemide hydrochloride, a novel anticonvulsant agent, and its major active metabolite, desglycinylremacemide, were measured simultaneously in brain tissue by high-performance liquid chromatography with UV detection. This reliable assay has applications in the pre-clinical neuropharmacokinetic and neuropharmacodynamic investigation of remacemide hydrochloride.

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Similar articles High-performance liquid chromatographic method for the simultaneous measurement of remacemide a novel anticonvulsant and cerebroprotectant and an active metabolite in human plasma.

Flynn JW, et al. J Chromatogr. PMID: Brain uptake and biotransformation of remacemide hydrochloride, a novel anticonvulsant. Heyn H, et al. Drug Metab Dispos. Electrophysiological effects of the anticonvulsant remacemide hydrochloride and its metabolite ARL AA on rat CA1 hippocampal neurons in vitro. Norris SK, et al. Quantitation of the novel anticonvulsant remacemide in rat and dog plasma and urine: application of the plasma methodology to measure the plasma protein binding of remacemide.

Wilson TC, et al. Remacemide hydrochloride: a novel antiepileptic agent. Davies JA. Gen Pharmacol. PMID: Review. Show more similar articles See all similar articles. Animals Actions. Male Actions. Mice Actions. Reproducibility of Results Actions. Sensitivity and Specificity Actions. Spectrophotometry, Ultraviolet Actions. Substances Acetamides Actions. Phenethylamines Actions. FPL Actions. Copy Download.

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